Small lectin ligands as a basis for applications in glycoscience and glycomedicine
Paul V. Murphy, Ashis Dhara, Liam S. Fitzgerald, Eoin Hever, Saidulu Konda, Kishan Mandal
Abstract
Glycan recognition by lectins mediates important biological events. This Tutorial Review aims to introduce lectin-ligand interactions and show how these molecular recognition events inspire innovations such as: (i) glycomimetic ligands; (ii) multivalent ligand agonists/antagonists; (iii) ligands for precision delivery of therapies to cells, where therapies include vaccines, siRNA and LYTACs (iv) development of diagnostics. A small number of case studies are selected to demonstrate principles for development of new ligands for applications inspired by knowledge of natural glycan ligand structure and function.
Topics & Concepts
GlycanLectinLigand (biochemistry)Computational biologyChemistryFunction (biology)Molecular recognitionNanotechnologyBiochemistryBiologyCell biologyReceptorGlycoproteinMoleculeMaterials scienceOrganic chemistryGlycosylation and Glycoproteins ResearchCarbohydrate Chemistry and SynthesisGalectins and Cancer Biology