Embracing Bayesian Methods in Clinical Trials
J. Jack Lee, Frank E. Harrell, Lisa M. LaVange, David J. Spiegelhalter
Abstract
This Perspective discusses the importance of the US Food and Drug Administration’s draft guidance on the use of bayesian methods in clinical trials because it underscores its commitment to modernizing clinical research.
Topics & Concepts
MedicineClinical trialBayesian probabilityPerspective (graphical)Food and drug administrationMedical physicsBayes' theoremDrug trialMEDLINEArtificial intelligenceDrug developmentIntensive care medicineMachine learningEndpoint DeterminationClinical judgmentClinical PracticeBayesian statisticsClinical decision makingManagement scienceResearch designClinical study designRisk analysis (engineering)Drug approvalPrecision medicineStatistical Methods in Clinical TrialsStatistical Methods and Bayesian InferenceMeta-analysis and systematic reviews