RGG-motif containing mRNA export factor Gbp2 acts as a translation repressor
Gopalakrishna Poornima, Gaurav Srivastava, Brinta Roy, Ishwarya Achappa Kuttanda, Iladeiti Kurbah, Purusharth I Rajyaguru
Abstract
translation systems in an RGG-motif dependent manner. Taken together, our results establish that the mRNA export factor Gbp2 has a vital role in repressing translation of mRNA. We propose that Gbp2 is a multifaceted RGG-motif protein responsible for translational repression without affecting mRNA levels.
Topics & Concepts
BiologyCell biologyEIF4GPolysomeRepressorTranslation (biology)RNA-binding proteinMessenger RNAMolecular biologyRNAGene expressionGeneticsGeneRibosomeRNA Research and SplicingRNA and protein synthesis mechanismsRNA modifications and cancer