Net release and uptake of xenometabolites across intestinal, hepatic, muscle, and renal tissue beds in healthy conscious pigs
Kelly E. Mercer, Gabriëlla A. M. Ten Have, Lindsay Pack, Renny S. Lan, Nicolaas E.P. Deutz, Sean H. Adams, Brian D. Piccolo
2020American Journal of Physiology-Gastrointestinal and Liver Physiology12 citationsDOIOpen Access PDF
Abstract
Xenometabolites from microbe origins influence host health and disease, but absorption and tissue uptake of these metabolites remain speculative. Results herein are the first to demonstrate in vivo organ uptake and release of these metabolites. We used a conscious catheterized pig model to confirm gastrointestinal origins for several xenometabolites (e.g., indolic compounds, 4-hydroxyphenyllactic acid, dodecanendioic acid, and phenylacetylgycine). Liver and kidney were major sites for xenometabolite uptake, likely highlighting liver conjugation metabolism and renal excretion.
Topics & Concepts
KidneyInternal medicineMedicineBiochemical effects in animalsViral gastroenteritis research and epidemiologyLiver Disease Diagnosis and Treatment