Targeting Scaffolding Functions of Enzymes Using PROTAC Approaches
Chiho Kim, Xudong Wang, Zhengshuai Liu, Shan Zha, Yonghao Yu
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVViewpointNEXTTargeting Scaffolding Functions of Enzymes Using PROTAC ApproachesChiho KimChiho KimDepartment of Molecular Pharmacology and Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York 10032, United StatesMore by Chiho Kim, Xu-Dong WangXu-Dong WangDepartment of Molecular Pharmacology and Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York 10032, United StatesMore by Xu-Dong Wang, Zhengshuai LiuZhengshuai LiuDepartment of Molecular Pharmacology and Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York 10032, United StatesMore by Zhengshuai Liu, Shan ZhaShan ZhaInstitute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York 10032, United StatesDepartment of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York 10032, United StatesDepartment of Pathology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York 10032, United StatesDepartment of Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York 10032, United StatesDepartment of Immunology and Microbiology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York 10032, United StatesMore by Shan Zha, and Yonghao Yu*Yonghao YuDepartment of Molecular Pharmacology and Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York 10032, United States*Email: [email protected]More by Yonghao Yuhttps://orcid.org/0000-0001-8414-4666Cite this: Biochemistry 2023, 62, 3, 561–563Publication Date (Web):July 14, 2022Publication History Received21 June 2022Published online14 July 2022Published inissue 7 February 2023https://pubs.acs.org/doi/10.1021/acs.biochem.2c00366https://doi.org/10.1021/acs.biochem.2c00366article-commentaryACS PublicationsCopyright © 2022 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views4158Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (1 MB) Get e-AlertscloseSUBJECTS:Degradation,Genetics,Inhibition,Inhibitors,Peptides and proteins Get e-Alerts