Advancements in genetic research by the Hispanic Community Health Study/Study of Latinos: A 10-year retrospective review
Hridya Rao, Margaret C. Weiss, Jee‐Young Moon, Krista M. Perreira, Martha L. Daviglus, Robert M. Kaplan, Kari E. North, Maria Argos, Lindsay Fernández‐Rhodes, Tamar Sofer
Abstract
The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a multicenter, longitudinal cohort study designed to evaluate environmental, lifestyle, and genetic risk factors as they relate to cardiometabolic and other chronic diseases among Hispanic/Latino populations in the United States. Since the study's inception in 2008, as a result of the study's robust genetic measures, HCHS/SOL has facilitated major contributions to the field of genetic research. This 10-year retrospective review highlights the major findings for genotype-phenotype relationships and advancements in statistical methods owing to the HCHS/SOL. Furthermore, we discuss the ethical and societal challenges of genetic research, especially among Hispanic/Latino adults in the United States. Continued genetic research, ancillary study expansion, and consortia collaboration through HCHS/SOL will further drive knowledge and advancements in human genetics research.