Hypoglycemic effect of glycyrrhizic acid, a natural non-carbohydrate sweetener, on streptozotocin-induced diabetic mice
Wei Zhang, Ting Li, Xiaojing Zhang, Zhen‐Yuan Zhu
Abstract
, which was close to the positive control (acarbose). In addition, GZA could reduce the fasting blood glucose of T2DM mice by increasing insulin sensitivity, increasing glucose tolerance, significantly decreasing serum triglyceride (TG), total cholesterol (TC), and low density lipoprotein cholesterol (LDL-C) contents, and increasing high density lipoprotein cholesterol (HDL-C) content. At the same time, it could also repair damaged organs to some extent. Therefore, GZA has broad application prospects in the treatment of T2DM.
Topics & Concepts
ChemistryChromatographyHydrolysisStreptozotocinHigh-performance liquid chromatographySilica gelEnzymatic hydrolysisAcid hydrolysisColumn chromatographyCarbohydrateBiochemistryDiabetes mellitusMedicineEndocrinologyPharmacological Effects of Natural CompoundsChromatography in Natural ProductsNatural product bioactivities and synthesis