Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Vladimı́r Frecer, Stanislav Miertuš
Abstract
Structure-based design of SARS-CoV-2 main protease inhibitors identified hydantoin, benzothiazine and cresol moieties as promising residues of new peptidomimetic inhibitors.
Topics & Concepts
PeptidomimeticProteaseSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)Hydantoin2019-20 coronavirus outbreakChemistryCombinatorial chemistryVirologyEnzymeStereochemistryPharmacologyBiochemistryMedicinePeptideOutbreakDiseaseInfectious disease (medical specialty)PathologyComputational Drug Discovery MethodsClick Chemistry and ApplicationsChemical Synthesis and Analysis