Racial and Ethnic Differences in the Population-Attributable Fractions of Alzheimer Disease and Related Dementias
Song‐Yi Park, Veronica Wendy Setiawan, Eileen M. Crimmins, Lon R. White, Anna H. Wu, Iona Cheng, Burcu F. Darst, Christopher A. Haiman, Lynne R. Wilkens, Loı̈c Le Marchand, Unhee Lim
Abstract
BACKGROUND AND OBJECTIVES: Previous studies estimated that modifiable risk factors explain up to 40% of the dementia cases in the United States and that this population-attributable fraction (PAF) differs by race and ethnicity-estimates of future impact based on the risk factor prevalence in contemporary surveys. The aim of this study was to determine the race-specific and ethnicity-specific PAF of late-onset Alzheimer disease and related dementias (ADRDs) based on the risk factor prevalence and associations observed on the same individuals within a prospective cohort. METHODS: ε4 for a subset. RESULTS: ε4, which together with nongenetic risk factors accounted for 30.6% (25.8-35.1) of ADRD. DISCUSSION: Known risk factors explained about a third of the ADRD cases but with unequal distributions across racial and ethnic groups.