Challenging current scientific practice: how a shift in research methodology could reduce animal use
S. Helene Richter
Abstract
The 3R principles provide an ethical framework for animal research throughout the world. However, despite the increasing awareness of these principles, there is still a lot of room for improving their implementation, especially when it comes to reduction. By combining Bayesian statistics with a shift in experimental design, here we present an entirely new idea to reduce animal numbers within experiments.
Topics & Concepts
Computer scienceParadigm shiftAnimal testingAnimal welfareRisk analysis (engineering)Data scienceEngineering ethicsManagement scienceBusinessBiologyEngineeringEpistemologyEcologyPhilosophyAnimal testing and alternativesComputational Drug Discovery MethodsEffects and risks of endocrine disrupting chemicals