Design, synthesis and biological evaluation of covalent peptidomimetic 3CL protease inhibitors containing nitrile moiety
Mengwei Zhu, Tiantian Fu, Mengyuan You, Junyuan Cao, Hanxi Yang, Xinyao Chen, Qiumeng Zhang, Yechun Xu, Xiangrui Jiang, Leike Zhang, Haixia Su, Yan Zhang, Jingshan Shen
Topics & Concepts
ChemistryPeptidomimeticNitrileMoietyCovalent bondProteaseStereochemistryCombinatorial chemistryChemical synthesisEnzyme inhibitorEnzymeBiochemistryOrganic chemistryIn vitroPeptideClick Chemistry and ApplicationsMonoclonal and Polyclonal Antibodies ResearchComputational Drug Discovery Methods