Model-Based Exposure-Response Assessment for Spectinamide 1810 in a Mouse Model of Tuberculosis
Santosh Wagh, Chetan Rathi, Pradeep B. Lukka, Keyur Parmar, Zaid H. Temrikar, Jiuyu Liu, Michaël Scherman, Richard Lee, Gregory T. Robertson, Anne J. Lenaerts, Bernd Meibohm
Abstract
Despite decades of research, tuberculosis remains a leading cause of death from a single infectious agent. Spectinamides are a promising novel class of antituberculosis agents, and the lead spectinamide 1810 has demonstrated excellent efficacy, safety, and drug-like properties in numerous in vitro and in vivo assessments in mouse models of tuberculosis.
Topics & Concepts
In vivoPharmacodynamicsPharmacologyPharmacokineticsTuberculosisMinimum inhibitory concentrationMycobacterium tuberculosisDosingPopulationMedicineDrugIn vitroArea under the curveImmunologyMicrobiologyBiologyAntibioticsPathologyBiochemistryEnvironmental healthBiotechnologyAntibiotics Pharmacokinetics and EfficacyCancer therapeutics and mechanismsTuberculosis Research and Epidemiology