Inhibitory activity of flavonoids against human sucrase-isomaltase (α-glucosidase) activity in a Caco-2/TC7 cellular model
Carina Proença, Ana T. Rufino, José Miguel P. Ferreira de Oliveira, Marisa Freitas, Pedro Alexandrino Fernandes, Artur M. S. Silva, Eduarda Fernandes
Abstract
Flavonoids may be effective inhibitors of SI in Caco-2/TC7 cells when using natural substrates maltose and sucrose. The chemical features that favor the SI inhibition by flavonoids are the presence of –OH groups at C-3, C-3′, C-4′, C-7 and C-8.
Topics & Concepts
SucraseMaltoseAlpha-glucosidaseIC50FlavonoidBiochemistryPostprandialChemistryEnzymeIn vitroBiologyDiabetes mellitusAntioxidantEndocrinologyNatural Antidiabetic Agents StudiesPhytochemicals and Antioxidant ActivitiesDiet, Metabolism, and Disease