HP(O)Ph<sub>2</sub>/H<sub>2</sub>O-promoted hydrodefluorination of trifluoromethyl alkenes
Xue‐Qiang Chu, Li-Wen Sun, Yulan Chen, Jiawei Chen, Ying Xuan, Mengtao Ma, Zhi‐Liang Shen
Abstract
An efficient transition-metal-free hydrodefluorination reaction of trifluoromethyl alkenes for accessing gem -difluoroalkenes is developed. It was surprising to find that the phosphoryl anion is able to mediate the defluorination.
Topics & Concepts
TrifluoromethylChemistryMedicinal chemistryOrganic chemistryAlkylFluorine in Organic ChemistryInorganic Fluorides and Related Compounds