ARID1A mutation drives gastric tumorigenesis via activating type 2 immune dominant microenvironment
Junya Arai, Yoku Hayakawa, Nobumi Suzuki, Hiroto Kinoshita, Masahiro Hata, Ken Kurokawa, Yuki Matsushita, Sohei Abe, Yukiko Oya, Mayo Tsuboi, Sozaburo Ihara, Yusuke Iwata, K. Murakami, T. Shiokawa, Chihiro Shiomi, Chie Uekura, Keisuke Yamamoto, Hiroaki Fujiwara, Satoshi Kawamura, Hayato Nakagawa, Tsuneo Ikenoue, Hiroaki Tateno, Tetsuo Ushiku, Hideaki Ijichi, Yoshihiro Hirata, Masato Kasuga, Gloria H. Su, Timothy C. Wang, Mitsuhiro Fujishiro
Abstract
-mutated GCs and represents a promising therapeutic target.
Topics & Concepts
ARID1ACarcinogenesisImmune systemMutationTumor microenvironmentBiologyImmune escapeChemistryCancer researchCell biologyGeneticsCancerGenePeptidase Inhibition and AnalysisChromatin Remodeling and CancerCancer Mechanisms and Therapy