Localization of Metabolites of Human Kidney Tissue with Infrared Laser-Based Selected Reaction Monitoring Mass Spectrometry Imaging and Silver-109 Nanoparticle-Based Surface Assisted Laser Desorption/Ionization Mass Spectrometry Imaging
Joanna Nizioł, Jan Sunner, Iwona B. Beech, Krzysztof Ossoliński, Anna Ossolińska, Tadeusz Ossoliński, Aneta Płaza‐Altamer, Tomasz Ruman
Abstract
AgNPET) in full-scan MS mode. The acquired MS images revealed differences in abundances of selected metabolites between cancerous and noncancerous regions of the kidney tissue. Importantly, the two imaging methods offered similar results. This study demonstrates the applicability of the novel ambient LARESI SRM/MRM MSI method to both investigating and discovering cancer biomarkers in human tissue.
Topics & Concepts
ChemistryMass spectrometry imagingMonoisotopic massMass spectrometrySelected reaction monitoringTandem mass spectrometryChromatographyAnalytical Chemistry (journal)Mass Spectrometry Techniques and ApplicationsMetabolomics and Mass Spectrometry StudiesAdvanced Proteomics Techniques and Applications