BRCA2 gene mutation in cancer
Chunbao Xie, Jiangrong Luo, Yangjun He, Lingxi Jiang, Ling Zhong, Yi Shi
Abstract
Breast cancer susceptibility gene 2 (BRCA2) is the main gene associated with hereditary breast cancers. However, a mutation in BRCA2 has also been found in other tumors, such as ovarian, pancreatic, thyroid, gastric, laryngeal, and prostate cancers. In this review, we discuss the biological functions of BRCA2 and the role of BRCA2 mutations in tumor progression and therapy.
Topics & Concepts
MedicineBreast cancerMutationBRCA2 ProteinOncologyOvarian cancerCancerGeneInternal medicineProstate cancerGene mutationCancer researchGermline mutationGeneticsBiologyBRCA gene mutations in cancerCRISPR and Genetic EngineeringPARP inhibition in cancer therapy