Aliphatic Polyester‐Based Materials for Enhanced Cancer Immunotherapy
Ai Lin Chin, Xiaoqian Wang, Rong Tong
Abstract
Poly(lactic acid) (PLA) and its copolymer, poly(lactic-co-glycolic acid) (PLGA), based aliphatic polyesters have been extensively used for biomedical applications, such as drug delivery system and tissue engineering, thanks to their biodegradability, benign toxicity, renewability, and adjustable mechanical properties. A rapidly growing field of cancer research, the development of therapeutic cancer vaccines or treatment modalities is aimed to deliver immunomodulatory signals that control the quality of immune responses against tumors. Herein, the progress and applications of PLA and PLGA are reviewed in delivering immunotherapeutics to treat cancers.
Topics & Concepts
PLGAPolyesterGlycolic acidDrug deliveryImmunotherapyCancerLactic acidImmune systemChemistryNanotechnologyMaterials scienceMedicineNanoparticleOrganic chemistryImmunologyBiologyInternal medicineBacteriaGeneticsNanoparticle-Based Drug DeliveryRNA Interference and Gene DeliveryImmunotherapy and Immune Responses