Recyclable Polymer Supported DMAP Catalyzed Cascade Synthesis of α-Pyrones
Anshul Jain, Akanksha Kumari, Suman K. Saha, Khyati Shukla, Ashwani Chauhan, Ramesh K. Metre, Nirmal K. Rana
Abstract
Polymer-supported catalysts have emerged as one of the sustainable and cost-effective alternatives in organic synthetic chemistry. We have developed the first polymer-supported DMAP catalyzed one-pot synthesis of diversely substituted α-pyrones. The cascade approach involves C5 conjugate addition of 5 H -oxazol-4-ones to α,β-unsaturated-β-ketoesters followed by lactonization/elimination.
Topics & Concepts
CascadeConjugateCatalysisCombinatorial chemistryChemistryPolymerOrganic chemistryMathematicsMathematical analysisChromatographySynthetic Organic Chemistry MethodsAsymmetric Synthesis and CatalysisCatalytic C–H Functionalization Methods