Recent Advances in the Synthesis of 5‐Membered <i>N</i> ‐Heterocycles via Rhodium Catalysed Cascade Reactions
Deepak Ranjan Mishra, Bhabani Shankar Panda, Sabita Nayak, Jasmine Panda, Seetaram Mohapatra
Abstract
Abstract Five membered N ‐heterocycles are significant targets in organic synthesis because of their ubiquitous existence in bioactive natural products and pharmaceuticals. Over the past decade a compelling attractiveness has grown to develop rhodium complex catalysed efficient and atom‐economic chemistry to access structurally diverse N ‐heterocyclic frameworks. This present review enlightens notable progresses and advances in synthesis of 5‐membered N ‐heterocycles via rhodium catalysed cascade reactions (annulations, C−H/C−C activation, cycloaddition, rearrangement, cyclization, metathesis) from 2018–2021.
Topics & Concepts
RhodiumChemistryCycloadditionCascadeAtom economyMetathesisCombinatorial chemistrySalt metathesis reactionOrganic synthesisCatalysisStereochemistryOrganic chemistryPolymerizationChromatographyPolymerCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsAsymmetric Hydrogenation and Catalysis