A graphene-based dengue immunosensor using plant-derived envelope glycoprotein domain III (EDIII) as the novel probe antigen
Qi Yan Siew, Shi Hui Tan, Ee Leen Pang, Hwei‐San Loh, Michelle T.T. Tan
Abstract
. The immunosensor also showed high specificity towards DENV IgG, capable of differentiating DENV IgG from the antibodies of other infectious diseases including the similarly structured Zika virus (ZIKV). The ability of the immunosensor to detect dengue antibodies in serum samples was also verified by conducting tests on mouse serum samples. The proposed immunosensor was able to provide a binary (positive/negative) response towards the serum samples comparable to the conventional enzyme-linked immunosorbent assay (ELISA), indicating promising potential for realistic applications.
Topics & Concepts
Dengue feverGlycoproteinAntigenDengue virusVirologyChemistryEnvelope (radar)BiologyBiochemistryImmunologyComputer scienceTelecommunicationsRadarMosquito-borne diseases and controlAdvanced biosensing and bioanalysis techniquesVirology and Viral Diseases