Structural modulation of membrane-intercalating conjugated oligoelectrolytes decouples outer membrane permeabilizing and antimicrobial activities
Alex S. Moreland, Jakkarin Limwongyut, Samuel J. Holton, Guillermo C. Bazan
Abstract
We report a series of membrane-intercalating conjugated oligoelectrolytes (MICOEs) to probe how structural features impact bacterial membrane integrity and antibiotic activity. Minimum inhibitory concentrations (MICs) and outer membrane (OM) permeability correlated to different structural parameters suggesting that the antimicrobial mechanism is not related to OM permeabilization. However, lipid order parameters and MICs correlated to the same structural feature suggesting a possible link.
Topics & Concepts
MembraneAntimicrobialChemistryConjugated systemBacterial outer membraneBiophysicsIntercalation (chemistry)Membrane integrityBiochemistryBiologyOrganic chemistryPolymerEscherichia coliGeneAntimicrobial agents and applicationsLuminescence and Fluorescent MaterialsAdvanced biosensing and bioanalysis techniques