Silver-Catalyzed Dibromotrifluoromethoxylation of Terminal Alkynes
Feng Wang, Yuecong Guo, Yutong Zhang, Pingping Tang
Abstract
A silver-catalyzed dibromotrifluoromethoxylation of terminal alkynes has been reported, which provides the corresponding 1,1-dibromo-2-(trifluoromethoxy)alkenes in good yields and high regioselectivity under mild reaction conditions. The reaction exhibits a broad substrate scope and applies to late-stage trifluoromethoxylation of complex small molecules. Moreover, the products can be further modified, which provides a convenient method for the synthesis of compounds containing the OCF3 group.
Topics & Concepts
RegioselectivityCatalysisSubstrate (aquarium)Terminal (telecommunication)ChemistryCombinatorial chemistryReaction conditionsScope (computer science)MoleculeOrganic chemistryComputer scienceTelecommunicationsOceanographyProgramming languageGeologyFluorine in Organic ChemistryInorganic Fluorides and Related CompoundsCatalytic C–H Functionalization Methods