<i>S</i>-Adenosylmethionine: more than just a methyl donor
Yu‐Hsuan Lee, Daan Ren, Byungsun Jeon, Hung‐wen Liu
Abstract
subtle differences in their active sites. This review summarizes recent advances in the discovery of novel SAM utilizing enzymes that rely on Lewis acid/base chemistry as opposed to radical mechanisms of catalysis. The examples are categorized based on the presence of a methyltransferase fold and the role played by SAM within the context of known sulfonium chemistry.
Topics & Concepts
MethylationChemistryEnzymeComputational biologyBiochemistryBiologyDNAFolate and B Vitamins ResearchBiochemical and Molecular ResearchRNA modifications and cancer