Cetuximab-Ag<sub>2</sub>S quantum dots for fluorescence imaging and highly effective combination of ALA-based photodynamic/chemo-therapy of colorectal cancer cells
Mahshid Hashemkhani, Gözde Demirci, Ali Bayır, Abdullah Muti, Alphan Sennaroğlu, Layla Mohammad-Hadi, Elnaz Yaghini, Marilena Loizidou, Alexander J. MacRobert, Havva Yağcı Acar
Abstract
covalent linkages was also effective for PDT, but required a longer incubation time for the release of ALA in therapeutic doses. Phototoxicity was correlated with high levels of reactive oxygen species (ROS) and apoptotic/necrotic cell death. Hence, both AS-2MPA-ALA-Cet based PDT and AS-2MPA-ALA-Cet-5FU based chemo/PDT combination therapy coupled with strong NIR tracking of the nanoparticles demonstrate an exceptional therapeutic effect on CRC cells and excellent potential for synergistic multistage tumour targeting therapy.
Topics & Concepts
Photodynamic therapyCetuximabColorectal cancerQuantum dotCancer researchFluorescenceMaterials scienceCombination therapyFluorescence-lifetime imaging microscopyMedicineNanotechnologyCancerOncologyInternal medicineChemistryOpticsPhysicsOrganic chemistryNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesAdvanced Photocatalysis Techniques