Discovery of benzo[d]oxazol-2(3H)-one derivatives as a new class of TNIK inhibitors for the treatment of colorectal cancer
Xinling Luo, Ruicheng Yang, Yueshan Li, Liting Zhang, Shengyong Yang, Linli Li
Topics & Concepts
Wnt signaling pathwayChemistryColorectal cancerIC50Drug discoveryCancer researchKinaseCancerWestern blotSignal transductionPharmacologyBiochemistryInternal medicineBiologyMedicineIn vitroGeneCancer-related Molecular PathwaysMechanisms of cancer metastasisCancer Mechanisms and Therapy