Immunity to Seasonal Coronavirus Spike Proteins Does Not Protect from SARS-CoV-2 Challenge in a Mouse Model but Has No Detrimental Effect on Protection Mediated by COVID-19 mRNA Vaccination
Fatima Amanat, Jordan J Clark, Juan Manuel Carreño, Shirin Strohmeier, Temima Yellin, Philip Meade, Disha Bhavsar, Hiromi Muramatsu, Weina Sun, Lynda Coughlan, Norbert Pardi, Florian Krammer
Abstract
The impact that immunity against seasonal coronaviruses has on both susceptibility to SARS-CoV-2 infection as well as on COVID-19 vaccination is unclear. This study provides insights into both questions in a mouse model of SARS-CoV-2.
Topics & Concepts
CoronavirusVaccinationImmunityBiologyHerd immunityVirologyBetacoronavirusImmune systemImmunologyCoronavirus disease 2019 (COVID-19)Infectious disease (medical specialty)DiseaseMedicinePathologySARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesAnimal Virus Infections Studies