Strategies for modifying the chimeric antigen receptor (CAR) to improve safety and reduce toxicity in CAR T cell therapy for cancer
Ali Sayadmanesh, Vahid Yekehfallah, Amir Valizadeh, Ali Abedelahi, Hajar Shafaei, Dariush Shanehbandi, Mohsen Basiri, Behzad Baradaran
Topics & Concepts
Chimeric antigen receptorCytokine release syndromeToxicitySuicide geneAntigenCell therapyImmunotherapyCancerCancer researchAdverse effectMonoclonal antibodyImmunologyImmune systemGenetic enhancementMedicineT cellBiologyCellPharmacologyAntibodyInternal medicineGeneGeneticsBiochemistryCAR-T cell therapy researchNanowire Synthesis and ApplicationsAdvancements in Semiconductor Devices and Circuit Design