Nitrogen atom insertion into indenes to access isoquinolines
Patrick Finkelstein, Julia C. Reisenbauer, Bence B. Botlik, Ori Green, Andri Florin, Bill Morandi
Abstract
We report a convenient protocol for a nitrogen atom insertion into indenes to afford isoquinolines. The strategy further enables the synthesis of pyridines from cyclopentadienes and a facile access to 15 N labelled isoquinolines.
Topics & Concepts
Nitrogen atomAtom (system on chip)ChemistryNitrogenCombinatorial chemistryMedicinal chemistryStereochemistryRing (chemistry)Computer scienceOrganic chemistryParallel computingChemical Synthesis and AnalysisCatalytic C–H Functionalization MethodsSynthesis and Biological Activity