Sulfur‐Promoted Synthesis of Benzoxazoles from 2‐Aminophenols and Aldehydes
Le Anh Nguyen, Thai Duy Dang, Quoc Anh Ngo, Thanh Bình Nguyễn
Abstract
Elemental sulfur (S 8 ) was found to be an excellent stoichiometric oxidant to promote oxidative condensation of 2‐aminophenols with a wide range of aldehydes, including aliphatic aldehyde such as cyclohexanecarboxaldehyde. The reactions were catalyzed by sodium sulfide in the presence of DMSO as an additive. The benzoxazole products were obtained in satisfactory yields. The reaction conditions could be applied to larger syntheses (10–50 mmol).
Topics & Concepts
ChemistryBenzoxazoleAldehydeStoichiometrySulfurSodium sulfideSulfideOrganic chemistryCatalysisCondensation reactionDimethyl sulfideCondensationThermodynamicsPhysicsSulfur-Based Synthesis TechniquesChemical Synthesis and ReactionsMulticomponent Synthesis of Heterocycles