Photoinduced Copper-Catalyzed Enantioconvergent Remote Alkynylation via 1,4-Heteroaryl Migration
Jianlin Chun, Yukun Li, Xiaofei Xie, Kang Guo, Daoyuan Zhao, Kang Chen, Yingguang Zhu
Abstract
-hydroxyphthalimide esters with terminal alkynes via 1,4-heteroaryl migration has been developed. A broad scope of heteroaryl-tethered chiral alkynes has been synthesized with good regio- and enantioselectivities. The chiral-ligand-coordinated copper species plays a dual role as both the photoredox and cross-coupling catalyst. This methodology provides a new platform for enantioconvergent remote alkynylations.
Topics & Concepts
AlkynylationChemistryCatalysisCopperLigand (biochemistry)Combinatorial chemistryOrganic chemistryReceptorBiochemistryCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques