Transition-metal-free synthesis of 5-amino-1,2,3-triazoles <i>via</i> nucleophilic addition/cyclization of carbodiimides with diazo compounds
Shilong Wang, Yuanyuan Zhang, Guixin Liu, Hui Xu, Lijuan Song, Jinchun Chen, Jiazhu Li, Zhen Zhang
Abstract
A facile and transition-metal-free synthesis of functionalized 5-amino-1,2,3-triazoles with good functional-group tolerance and regioselectivity <italic>via</italic> nucleophilic addition/cyclization has been described.
Topics & Concepts
ChemistryRegioselectivityDiazoNucleophilic additionNucleophileTransition metalFunctional groupCombinatorial chemistryNucleophilic substitutionMedicinal chemistryStereochemistryOrganic chemistryCatalysisPolymerCyclopropane Reaction MechanismsClick Chemistry and ApplicationsSynthesis and Catalytic Reactions