Effect of the Cationic Moiety on the Antimicrobial Activity ofSterically Hindered Isatin 3-Hydrazone Derivatives
А. В. Богданов, Marina Kadomtseva, С. В. Бухаров, Alexandra D. Voloshina, В. Ф. Миронов
Abstract
Abstract Water-soluble 1-(3,5-di-tert-butyl-4-hydroxybenzyl)isatin 3-acylhydrazones containing an acyclic, bicyclic, or pyridinium quaternary ammonium center in the acyl moiety showed antibacterial activity against some gram-positive bacteria. Derivatives with a 2,3-dimethylpyridine or diazabicyclooctane fragment exhibited the highest activity against S. aureus and B. cereus as expressed by the minimum bactericidal concentration and were 4 times more active than chloramphenicol.
Topics & Concepts
ChemistryIsatinMoietyPyridiniumHydrazoneAntimicrobialSteric effectsAntibacterial activityAmmoniumCationic polymerizationOrganic chemistryMedicinal chemistryStereochemistryCombinatorial chemistryBacteriaGeneticsBiologySynthesis and Biological EvaluationSynthesis and biological activityClick Chemistry and Applications