Simvastatin inhibits hepatic stellate cells activation by regulating the ferroptosis signaling pathway
Kensuke Kitsugi, Hidenao Noritake, Moe Matsumoto, Tomohiko Hanaoka, Masahiro Umemura, M. Yamashita, Shingo Takatori, Jun Ito, Kazuyoshi Ohta, Takeshi Chida, Takafumi Suda, Kazuhito Kawata
Topics & Concepts
SimvastatinGPX4Geranylgeranyl pyrophosphateMevalonic acidHepatic stellate cellFarnesyl pyrophosphateHMG-CoA reductaseMevalonate pathwayCell biologyChemistrySignal transductionDownregulation and upregulationOxidative stressBiologyPharmacologyCancer researchBiochemistryReductaseEndocrinologyGlutathione peroxidaseSuperoxide dismutaseEnzymeATP synthaseGeneFerroptosis and cancer prognosisCancer, Lipids, and MetabolismClusterin in disease pathology