Physiological dead space during exercise in patients with heart failure with preserved ejection fraction
Bryce N. Balmain, Andrew R. Tomlinson, James P. MacNamara, Satyam Sarma, Benjamin D. Levine, Linda S. Hynan, Tony G. Babb
Abstract
Calculating VD/VT with and without correcting for VDM yields quantitively and qualitatively different results, which could have an important impact on the interpretation of V/Q mismatch in HFpEF. The finding that V/Q mismatch and gas exchange efficiency worsened, as reflected by an increase in VD/VT VDM during exercise, has not been previously demonstrated in HFpEF. Thus, further studies are needed to investigate the mechanisms explaining the increase in VD/VT VDM during exercise in patients with HFpEF.
Topics & Concepts
Heart failureEjection fractionCardiologyHeart failure with preserved ejection fractionInternal medicineMedicinePhysical exerciseCardiovascular and exercise physiologyHeart Rate Variability and Autonomic ControlCardiovascular Function and Risk Factors