Synthesis of indolo[2,1-<i>α</i>]isoquinoline derivatives <i>via</i> metal-free radical cascade cyclization
Xuyang Hu, Haifeng Xu, Qiang Chen, Youlu Pan, Jian-Zhong Chen
Abstract
] isoquinoline derivatives bearing various functional groups were synthesized using this method in good to excellent yields. Based on a series of control experiments, a radical pathway was proposed to explain the experiment.
Topics & Concepts
IsoquinolineChemistryFunctional groupArylCombinatorial chemistryAlkylRadicalCascade reactionCatalysisCascadeStereochemistryOrganic chemistryPolymerChromatographyCatalytic C–H Functionalization MethodsSynthesis and Biological EvaluationOxidative Organic Chemistry Reactions