A dual-functional fluorescent biosensor based on enzyme-involved catalytic hairpin assembly for the detection of APE1 and miRNA-21
Xiaoyong Lu, Dan Li, Zewei Luo, Yixiang Duan
Abstract
for APE1 and 0.25 nM for miRNA-21 and APE1, respectively, and also exhibits good selectivity and stability for the two biomarkers. Thus, the biosensor has great potential to be applied as a new platform for cancer diagnosis.
Topics & Concepts
BiosensorFluorescenceEndonucleaseRecognition sequenceDetection limitAP sitemicroRNAChemistryDNAComputational biologyCombinatorial chemistryBiologyBiochemistryRestriction enzymeGenePhysicsChromatographyQuantum mechanicsAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryDNA and Nucleic Acid Chemistry