Pioneering Iodine-125-Labeled Nanoscale Covalent Organic Frameworks for Brachytherapy
Yijing Zhang, Jie Sheng, Fuwan Zhai, Xiaomei Wang, Long Chen, Cen Shi, Lei Chen, Linwei He, Ru Bai, Jian Xie, Zhifang Chai, Juan Diwu
Abstract
I-COF) demonstrated excellent cancer cell killing performance in vitro, and further experiments in vivo revealed a long tumor retention time and effective tumor treatment during the radiotherapy. The results indicate that radioiodine-labeled PEG-COF-Ag could be potentially applied in brachytherapy with a promising therapeutic effect.
Topics & Concepts
ChemistryBrachytherapyRadiochemistryCovalent bondPolymerNanomaterialsCovalent organic frameworkNuclear chemistryRadiation therapyNanotechnologyOrganic chemistryRadiologyMaterials scienceMedicineCovalent Organic Framework ApplicationsMetal-Organic Frameworks: Synthesis and ApplicationsHead and Neck Surgical Oncology