Acyl azide generation and amide bond formation in continuous-flow for the synthesis of peptides
Alejandro Mata, Ulrich Weigl, Oliver Flögel, Pius Baur, Christopher A. Hone, C. Oliver Kappe
Abstract
Acyl azides were safely generated by using nitrous acid in water and reacted<italic>in situ</italic>within a flow system. The acyl azide was efficiently extracted into the organic phase containing an amine nucleophile for a highly enantioselective peptide coupling.
Topics & Concepts
AzidePeptide bondAmine gas treatingAmideChemistryNucleophileCombinatorial chemistryContinuous flowPeptide synthesisEnantioselective synthesisOrganic chemistryPeptidePolymer chemistryCatalysisBiochemistryMechanicsPhysicsInnovative Microfluidic and Catalytic Techniques InnovationChemical Synthesis and AnalysisMonoclonal and Polyclonal Antibodies Research