JQ1, a selective inhibitor of BRD4, suppresses retinoblastoma cell growth by inducing cell cycle arrest and apoptosis
Yanyan Zhang, Sujuan Duan, Alan Jang, Longbing Mao, Xing Liu, Guofu Huang
Topics & Concepts
RetinoblastomaCyclin-dependent kinase 6ApoptosisCancer researchCell growthRetinoblastoma proteinCell cycleCell cycle checkpointChemotherapyBRD4In vivoCyclin-dependent kinase 2ChemistryMedicineBiologyInternal medicineBiochemistryBiotechnologyBromodomainGeneAcetylationProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysMultiple Myeloma Research and Treatments