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Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging

Denis A. Mogilenko, Oleg Shpynov, Prabhakar S. Andhey, Laura Arthur, Amanda Swain, Ekaterina Esaulova, Simone Brioschi, Irina Shchukina, Martina Kerndl, Monika Bambousková, Zhangting Yao, Anwesha Laha, Konstantin Zaitsev, Samantha Burdess, Susan Gillfilan, Sheila A. Stewart, Marco Colonna, Maxim N. Artyomov

2020Immunity691 citationsDOIOpen Access PDF

Topics & Concepts

BiologyImmune systemGranzyme BCytotoxic T cellCD8Mass cytometryEpigeneticsImmunologyPopulationFlow cytometryCell biologyGeneticsPhenotypeGeneIn vitroSociologyDemographySingle-cell and spatial transcriptomicsNeuroinflammation and Neurodegeneration MechanismsT-cell and B-cell Immunology
Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging | Litcius