Cancer-cell-membrane-camouflaged supramolecular self-assembly of antisense oligonucleotide and chemodrug for targeted combination therapy
Tianbao Chen, Jie Xu, Lijuan Zhu, Deyue Yan
Abstract
@CCM for drug-resistant breast tumor therapy. This CCM-camouflaged ASO/chemodrug nanoplatform provides a promising pathway for the targeted delivery of ASOs and chemodrugs for tumor combination therapy.
Topics & Concepts
OligonucleotideAmphiphileSupramolecular chemistryMitoxantroneBiophysicsCancer therapyChemistryCationic polymerizationAntisense therapyNanotechnologyMembraneCancer cellSelf-assemblyCellCancerCombinatorial chemistryMaterials scienceChemotherapyBiochemistryGeneBiologyPolymer chemistryCopolymerOrganic chemistryMoleculePolymerGeneticsLocked nucleic acidAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryNanoplatforms for cancer theranostics