A Transferable IncC-IncX3 Hybrid Plasmid Cocarrying <i>bla</i> <sub>NDM-4</sub> , <i>tet</i> (X), and <i>tmexCD3-toprJ3</i> Confers Resistance to Carbapenem and Tigecycline
Aki Hirabayashi, Trung Duc Dao, Taichiro Takemura, Futoshi Hasebe, Le Thi Huyen Trang, Nguyen Ha Thanh, Tran Huy Hoang, Keigo Shibayama, Ikuro Kasuga, Masato Suzuki
Abstract
on the same plasmid. A Klebsiella aerogenes isolate in Vietnam carried both these tigecycline resistance genes on a transferable plasmid leading to high-level resistance to multiple clinically important antimicrobials, including carbapenem and tigecycline, and could actually transfer the plasmid to other bacteria. The spread of such a multidrug resistance plasmid among bacterial pathogens should be of great concern because there are few antimicrobials to combat bacteria that have acquired the plasmid.
Topics & Concepts
TigecyclinePlasmidMicrobiologyMedicineBiologyGeneticsAntibioticsGeneAntibiotic Resistance in BacteriaPharmaceutical and Antibiotic Environmental ImpactsBacterial biofilms and quorum sensing