miR-150-PTPMT1-cardiolipin signaling in pulmonary arterial hypertension
Giusy Russomanno, Kyeong Beom Jo, Vahitha B. Abdul‐Salam, Claire C. Morgan, Jens Endruschat, Ute Schaeper, Ahmed Osman, Mai M. Alzaydi, Martin R. Wilkins, Beata Wójciak‐Stothard
Abstract
. In conclusion, we are the first to show that miR-150 supplementation attenuates pulmonary endothelial damage induced by vascular stresses and may be considered as a potential therapeutic strategy in PAH.
Topics & Concepts
CardiolipinCancer researchGene knockdownEndothelial dysfunctionHypoxia (environmental)Pulmonary hypertensionEndotheliumInflammationApoptosisBiologyIn vivoVascular endothelial growth factor BVascular endothelial growth factorMedicineImmunologyCell biologyInternal medicineEndocrinologyVascular endothelial growth factor AChemistryPhospholipidBiochemistryMembraneBiotechnologyOrganic chemistryOxygenVEGF receptorsPulmonary Hypertension Research and TreatmentsProtein Tyrosine PhosphatasesMicroRNA in disease regulation