Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo
Sarwish Rafiq, Oladapo Yeku, Hollie J. Jackson, Terence J. Purdon, Dayenne G. van Leeuwen, Dylan J. Drakes, Mei Song, Matthew M. Miele, Zhuoning Li, Pei Wang, Su Yan, Jingyi Xiang, Xiaojing Ma, Venkatraman Seshan, Ronald C. Hendrickson, Liu C, Renier J. Brentjens
Topics & Concepts
Chimeric antigen receptorCancer researchTumor microenvironmentImmune checkpointAutocrine signallingIn vivoParacrine signallingImmunotherapyImmune systemChemistryImmunologyMedicineReceptorBiologyTumor cellsInternal medicineBiotechnologyCAR-T cell therapy researchSilicon Carbide Semiconductor TechnologiesAdvancements in Semiconductor Devices and Circuit Design