Three-Component Synthesis of Some New Coumarin Derivatives as Anticancer Agents
Latifah Abdullah Alshabanah, Laila A. Al-Mutabagani, Sobhi M. Gomha, Hoda A. Ahmed
Abstract
A three-component reaction for the synthesis of novel 3-heteroaryl-coumarin utilizing acetylcoumarin synthon under ultrasonic irradiation was developed using chitosan-grafted poly(vinylpyridine) as an eco-friendly catalyst. The process is a simple, facile, efficient procedure for the preparation of compounds displaying a thiazole ring linked to coumarin moiety. Moreover, all the products were evaluated for their anticancer activities against HEPG2-1. The results revealed that three new compounds showed promising anticancer activities.
Topics & Concepts
CoumarinThiazoleMoietySynthonChemistryCombinatorial chemistryCatalysisChitosanRing (chemistry)Organic chemistryMulticomponent Synthesis of HeterocyclesSynthesis and biological activitySynthesis of Organic Compounds