Litcius/Paper detail

CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours

Roberta Zappasodi, Inna Serganova, Ivan Cohen, Masatomo Maeda, Masahiro Shindo, Yasin Şenbabaoğlu, McLane J. Watson, Avigdor Leftin, Rachana Maniyar, Svena Verma, Matthew Lubin, Myat Ko, Mayuresh Mane, Hong Zhong, Cailian Liu, Arnab Ghosh, Mohsen Abu-Akeel, Ellen Ackerstaff, Jason A. Koutcher, Ping‐Chih Ho, Greg M. Delgoffe, Ronald G. Blasberg, Jedd D. Wolchok, Taha Merghoub

2021Nature394 citationsDOIOpen Access PDF

Topics & Concepts

GlycolysisBlockadeCancer researchCD28T cellAnaerobic glycolysisCD8Cell biologyImmune systemDownregulation and upregulationBiologyChemistryImmunologyMetabolismBiochemistryReceptorGeneImmune Cell Function and InteractionT-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers