CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours
Roberta Zappasodi, Inna Serganova, Ivan Cohen, Masatomo Maeda, Masahiro Shindo, Yasin Şenbabaoğlu, McLane J. Watson, Avigdor Leftin, Rachana Maniyar, Svena Verma, Matthew Lubin, Myat Ko, Mayuresh Mane, Hong Zhong, Cailian Liu, Arnab Ghosh, Mohsen Abu-Akeel, Ellen Ackerstaff, Jason A. Koutcher, Ping‐Chih Ho, Greg M. Delgoffe, Ronald G. Blasberg, Jedd D. Wolchok, Taha Merghoub
Topics & Concepts
GlycolysisBlockadeCancer researchCD28T cellAnaerobic glycolysisCD8Cell biologyImmune systemDownregulation and upregulationBiologyChemistryImmunologyMetabolismBiochemistryReceptorGeneImmune Cell Function and InteractionT-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers