Influence of surface charge of graphene quantum dots on their uptake and clearance in melanoma cells
Lakshmi Narashimhan Ramana, Le N. M. Dinh, Vipul Agarwal
Abstract
. Using confocal microscopy and flow cytometry, we observed significantly faster and higher uptake of cationic GQDs compared to anionic GQDs. Consequently, relatively rapid clearance was observed in cells treated with anionic GQDs compared to those treated with cationic GQDs, highlighting the role of surface charge on GQDs in their uptake and clearance. Raman analysis of the cleared exocytosed GQDs revealed no sign of biodegradation of either type.
Topics & Concepts
GrapheneQuantum dotCharge (physics)MelanomaSurface chargeSurface (topology)NanotechnologyPhysicsCondensed matter physicsMaterials scienceQuantum mechanicsCancer researchMedicineMathematicsGeometryCarbon and Quantum Dots ApplicationsGraphene and Nanomaterials ApplicationsGraphene research and applications