Delivery of mitoceuticals or respiratory competent mitochondria to sites of neurotrauma
Samir P. Patel, Felicia M. Michael, Jenna L. Gollihue, W. Brad Hubbard, Patrick G. Sullivan, Alexander G. Rabchevsky
Abstract
Herein, we review evidence that targeting mitochondrial dysfunction with 'mitoceuticals' is an effective neuroprotective strategy following neurotrauma, and that isolated exogenous mitochondria can be effectively transplanted into host spinal cord parenchyma to increase overall cellular metabolism. We further discuss control measures to ensure greatest potential for mitochondrial transfer, notably using erodible thermogelling hydrogels to deliver respiratory competent mitochondria to the injured spinal cord.
Topics & Concepts
MitochondrionNeuroprotectionSpinal cord injurySpinal cordParenchymaRespiratory systemNeuroscienceCell biologyMedicineBiologyPathologyAnatomySpinal Cord Injury ResearchSpinal Dysraphism and MalformationsTraumatic Brain Injury and Neurovascular Disturbances