Advances in 3D Bioprinted Cardiac Tissue Using Stem Cell-Derived Cardiomyocytes
Jacqueline M. Bliley, Maria Stang, Anne Behre, Adam W. Feinberg
Abstract
The ultimate goal of cardiac tissue engineering is to generate new muscle to repair or replace the damaged heart. This requires advances in stem cell technologies to differentiate billions of cardiomyocytes, together with advanced biofabrication approaches such as 3D bioprinting to achieve the requisite structure and contractile function. In this concise review, we cover recent progress in 3D bioprinting of cardiac tissue using pluripotent stem cell-derived cardiomyocytes, key design criteria for engineering aligned cardiac tissues, and ongoing challenges in the field that must be addressed to realize this goal.
Topics & Concepts
Stem cell3D bioprintingCell biologyTissue engineeringBiomedical engineeringChemistryBiologyMedicine3D Printing in Biomedical ResearchTissue Engineering and Regenerative MedicinePluripotent Stem Cells Research